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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TGFB1I1 All Species: 27.27
Human Site: Y451 Identified Species: 54.55
UniProt: O43294 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O43294 NP_001035919.1 461 49814 Y451 Q E R A G K P Y C Q P C F L K
Chimpanzee Pan troglodytes XP_001159426 434 46626 P427 A G K P Y C Q P C F L K L F G
Rhesus Macaque Macaca mulatta XP_001113103 461 49794 Y451 Q E R A G K P Y C Q P C F L K
Dog Lupus familis XP_547052 461 49726 Y451 Q E R A G K P Y C Q P C F V K
Cat Felis silvestris
Mouse Mus musculus Q62219 461 50082 Y451 Q E R A S K P Y C Q P C F L K
Rat Rattus norvegicus Q99PD6 461 50104 Y451 Q E R A S K P Y C Q P C F L K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514315 225 25219 P218 A D K P Y C H P C F L K L F G
Chicken Gallus gallus P49024 559 61224 Y549 K E Q N D K P Y C Q N C F L K
Frog Xenopus laevis Q2TCH4 506 55983 Y496 R E H D E K P Y C Q A C Y A R
Zebra Danio Brachydanio rerio Q6P7E4 419 45574 K412 K K D K P L C K S H A F S P L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_724183 557 61985 Y547 K E Q K D K P Y C H T C F D K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q09476 413 46434 N406 F C H K C Y N N T Y A L T P A
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.1 99.5 93.2 N.A. 91.3 91.5 N.A. 45.3 43.4 43 22.7 N.A. 40.5 N.A. 36 N.A.
Protein Similarity: 100 94.1 99.5 95 N.A. 93 92.8 N.A. 47 55.9 56.7 34 N.A. 55.4 N.A. 51.8 N.A.
P-Site Identity: 100 6.6 100 93.3 N.A. 93.3 93.3 N.A. 6.6 66.6 46.6 0 N.A. 53.3 N.A. 0 N.A.
P-Site Similarity: 100 13.3 100 100 N.A. 93.3 93.3 N.A. 20 80 66.6 13.3 N.A. 66.6 N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 17 0 0 42 0 0 0 0 0 0 25 0 0 9 9 % A
% Cys: 0 9 0 0 9 17 9 0 84 0 0 67 0 0 0 % C
% Asp: 0 9 9 9 17 0 0 0 0 0 0 0 0 9 0 % D
% Glu: 0 67 0 0 9 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 9 0 0 0 0 0 0 0 0 17 0 9 59 17 0 % F
% Gly: 0 9 0 0 25 0 0 0 0 0 0 0 0 0 17 % G
% His: 0 0 17 0 0 0 9 0 0 17 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 25 9 17 25 0 67 0 9 0 0 0 17 0 0 59 % K
% Leu: 0 0 0 0 0 9 0 0 0 0 17 9 17 42 9 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 9 9 0 0 9 0 0 0 0 % N
% Pro: 0 0 0 17 9 0 67 17 0 0 42 0 0 17 0 % P
% Gln: 42 0 17 0 0 0 9 0 0 59 0 0 0 0 0 % Q
% Arg: 9 0 42 0 0 0 0 0 0 0 0 0 0 0 9 % R
% Ser: 0 0 0 0 17 0 0 0 9 0 0 0 9 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 9 0 9 0 9 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 17 9 0 67 0 9 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _